SOC

Surgery on Children Journal aims to publish issues related to Pediatric Surgery, Pediatric Neurosurgery, Pediatric Plastic Surgery, Pediatric Cardiovascular Surgery, Pediatric Orthopedic Surgery, Pediatric Vascular Surgery, Pediatric Gynecology and Obstetrics, Pediatric Ear Nose Throat, Ophthalmology, Pediatric Anesthesiology and Reanimation, Pediatric Urology, Pediatric Surgical Intensive Care Clinic, and other clinical surgery fields on children of the highest scientific and clinical value at an international level and accepts articles on these topics.

EndNote Style
Index
Original Article
Identification of low-risk pediatric patients with suspected acute appendicitis using the alvarado score: a diagnostic accuracy study
Aims: Acute appendicitis (AA) remains a major diagnostic challenge in children because of its variable clinical presentation and overlap with other causes of abdominal pain. This study aimed to evaluate the diagnostic performance of the Alvarado score (AS) in children with suspected AA.
Methods: This retrospective study included 737 pediatric patients presenting with abdominal pain between January 2019 and December 2023. Patients were classified into the acute appendicitis (AA) and nonspecific abdominal pain (NAP) groups. The diagnostic performance of the AS was assessed using receiver operating characteristic (ROC) analysis. Clinically relevant rule-out and rule-in thresholds based on previously published literature were evaluated.
Results: A total of 104 patients were diagnosed with AA and 633 with NAP. The median AS was significantly higher in the AA group than in the NAP group (8 [IQR 7–8] vs 3 [IQR 2–4]; p < 0.001). ROC analysis demonstrated excellent diagnostic performance of the AS, with an area under the curve (AUC) of 0.979 (95% CI 0.961–0.996; p < 0.001). An AS threshold of ?4 demonstrated a sensitivity of 98.1% and a a negative predictive value (NPV) of 99.6%, whereas a threshold of ?6 demonstrated a specificity of 96.5% and a positive likelihood ratio of 27.2.
Conclusion: The AS demonstrated excellent diagnostic performance and may serve as a useful adjunctive tool for the initial risk stratification of children with suspected AA. In particular, an AS ?4 was associated with a very low probability of AA and may help identify selected patients who could potentially avoid immediate imaging. Prospective multicenter studies are needed to validate these findings.


1. Nasiri S, Mohebbi F, Sodagari N, et al. Diagnostic values of ultrasound and the modified Alvarado scoring system in acute appendicitis. Int J Emerg Med. 2012;5(1):26. doi:10.1186/1865-1380-5-26
2. Kırkıl C, Karabulut K, Aygen E, et al. Appendicitis scores may be useful in reducing the costs of treatment for right lower quadrant pain. Ulus Travma Acil Cerrahi Derg. 2013;19:13-19. doi:10.5505/tjtes.2013.88714.
3. Neilson IR, Laberge JM, Nguyen LT, et al. Appendicitis in children: current therapeutic recommendations. J Pediatr Surg. 1990;25(11):1113-1116. doi:10.1016/0022-3468(90)90742-r
4. Podda M, Pisanu A, Sartelli M, et al. Diagnosis of acute appendicitis based on clinical scores: is it a myth or reality? Acta Biomed. 2021;92: e2021231. doi:10.23750/abm.v92i4.11666
5. Martin AE, Vollman D, Adler B, et al. CT scans may not reduce the negative appendectomy rate in children. J Pediatr Surg. 2004;39(6):886-890. doi:10.1016/j.jpedsurg.2004.02.034
6. Harel S, Mallon M, Langston J, Blutstein R, Kassutto Z, Gussow J. Factors contributing to nonvisualisation of the appendix on ultrasound in children with suspected appendicitis. Pediatr Emerg Care. 2022;38(2): e678-e682. doi:10.1097/PEC.0000000000002394
7. Bal A, Anil M, Nartürk M, et al. Importance of clinical decision making by experienced pediatric surgeons when children are suspected of having acute appendicitis: the reality in a high-volume pediatric emergency department. Pediatr Emerg Care. 2017;33(9):e38-e42. doi:10.1097/PEC.0000000000000763
8. Memon AZ, Irfan S, Fatima K, et al. Acute appendicitis: diagnostic accuracy of Alvarado scoring system. Asian J Surg. 2013;36(4):144-149. doi:10.1016/j.asjsur.2013.04.004
9. Alvarado A. A practical score for the early diagnosis of acute appendicitis. Ann Emerg Med. 1986;15(5):557-564. doi:10.1016/s0196-0644(86)80993-3
10. Bai S, Hu S, Zhang Y, et al. The value of the Alvarado score for the diagnosis of acute appendicitis in children: a systematic review and meta-analysis. J Pediatr Surg. 2023;58(10):1886-1892. doi:10.1016/j.jpedsurg.2023.02.060
11. Expert Panel on Pediatric Imaging:, Koberlein GC, Trout AT, et al. ACR Appropriateness Criteria® suspected appendicitis-child. J Am Coll Radiol 2019;16(5S)S252-S263 doi:10.1016/j.jacr.2019.02.022
12. Fallon SC, Kim ME, Hallmark CA, et al. Correlating surgical and pathological diagnoses in pediatric appendicitis. J Pediatr Surg. 2015; 50(4):638-641. doi:10.1016/j.jpedsurg.2014.11.001
13. Estey A, Poonai N, Lim R. Appendix not seen: the predictive value of secondary inflammatory sonographic signs. Pediatr Emerg Care. 2013; 29(4):435-439. doi:10.1097/PEC.0b013e318289e8d5
14. Puylaert JBCM. Acute appendicitis: US evaluation using graded compression. Radiology. 1986;158(2):355-360. doi:10.1148/radiology.158.2.2934762
15. Wiersma F, Srámek A, Holscher HC. US features of the normal appendix and surrounding area in children. Radiology. 2005;235(3):1018-1022. doi:10.1148/radiol.2353040086
16. Pernía J, Cancho T, Segovia I, et al. Predictive values of indirect ultrasound signs for low risk of acute appendicitis in paediatric patients without visualisation of the appendix on ultrasound. Emerg Med J. 2024;41(8):475-480. doi:10.1136/emermed-2023-213466
17. Gorter RR, Eker HH, Gorter-Stam MA, et al. Diagnosis and management of acute appendicitis. EAES consensus development conference 2015. Surg Endosc. 2016;30(11):4668-4690. doi:10.1007/s00464-016-5245-7
18. Noori IF, Jabbar AS, Nasser AA. Clinical scores (Alvarado and AIR scores) versus imaging (ultrasound and CT scan) in the diagnosis of equivocal cases of acute appendicitis: a randomized controlled study. Ann Med Surg (Lond). 2023;85(4):676-683. doi:10.1097/MS9.0000000000000270
19. Verghese A, Charlton B, Kassirer JP, Ramsey M, Ioannidis JPA. Inadequacies of physical examination as a cause of medical errors and adverse events: a collection of vignettes. Am J Med. 2015;128(12):1322-1324.e3. doi:10.1016/j.amjmed.2015.06.004
20. Khan SA, Ashraf R, Hassaan N, Naseer M, Azad MH, Javed H. The role of neutrophil-to-lymphocyte ratio in the diagnosis of acute appendicitis. Cureus. 2023;15(12):e51164. doi:10.7759/cureus.51164
21. Zouari M, Issaoui A, Hbaieb M, et al. Predictive factors of acute appendicitis in children with non-visualised appendix on ultrasound: a prospective cohort study. Surg Infect (Larchmt). 2024;25(1):26-31. doi:10.1089/sur.2023.295
22. Téoule P, Laffolie J, Rolle U, et al. Acute appendicitis in childhood and adulthood. Dtsch Arztebl Int. 2020;117(45):764-774. doi:10.3238/arztebl.2020.0764
23. El-Gohary Y, Molina M, Chang J, et al. The use of computed tomography versus clinical acumen in diagnosing appendicitis in children: a two-institution international study. J Pediatr Surg. 2021;56(8):1356-1361. doi:10.1016/j.jpedsurg.2020.09.061
24. Stephen AE, Segev DL, Ryan DP, et al. The diagnosis of acute appendicitis in a pediatric population: to CT or not to CT. J Pediatr Surg. 2003;38(3):367-371. doi:10.1053/jpsu.2003.50110
25. Russell WS, Schuh AM, Hill JG, et al. Clinical practice guidelines for pediatric appendicitis evaluation can decrease computed tomography utilization while maintaining diagnostic accuracy. Pediatr Emerg Care. 2013;29(5):568-573. doi:10.1097/PEC.0b013e31828e5718
26. Samuel M. Pediatric appendicitis score. J Pediatr Surg. 2002;37(6):877-881. doi:10.1053/jpsu.2002.32893
Volume 3, Issue 3, 2026
Page : 82-87
_Footer