SOC
Surgery on Children

Surgery on Children Journal aims to publish issues related to Pediatric Surgery, Pediatric Neurosurgery, Pediatric Plastic Surgery, Pediatric Cardiovascular Surgery, Pediatric Orthopedic Surgery, Pediatric Vascular Surgery, Pediatric Gynecology and Obstetrics, Pediatric Ear Nose Throat, Ophthalmology, Pediatric Anesthesiology and Reanimation, Pediatric Urology, Pediatric Surgical Intensive Care Clinic, and other clinical surgery fields on children of the highest scientific and clinical value at an international level and accepts articles on these topics.

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Original Article
Comparison of short-chain fatty acid (SCFA) patterns in children with and without hirschsprung’s disease
Abstract
Aims: Hirschsprung’s disease (HD) is a congenital gastrointestinal anomaly that causes morbidity and increases the risk of mortality. The increased risk of infection in HD is related to several factors, including dysbiosis of the intestinal microbiota, which plays an important role in maintaining intestinal function through the production of short-chain fatty acids (SCFAs). This study aimed to determine the differences in SCFA levels in children with HD and children without HD.
Methods: This study used an observational analytic cross-sectional design. The subjects were pediatric patients treated at Cipto Mangunkusomo Hospital from January to June 2024 who met the inclusion and exclusion criteria. A total of 17 pediatric patients were included, consisting of 9 children with HD and 8 children without HD. Fecal SCFA levels were analyzed and compared between the two groups.
Results: SCFA levels in children with HD (2.4 ± 1.6) were significantly lower than in children without HD (7.9 ± 2.4) (p < 0.05). There were no statistically significant differences (p > 0.05) between the HD group (n = 9) and the non-HD group (n = 8) in individual SCFA components, including butyrate, propionate, valerate, and acetate levels.
Conclusion: Children with Hirschsprung’s disease have significantly lower total fecal SCFA levels compared to children without Hirschsprung’s disease, while no significant differences were found in individual SCFA components.

Keywords : Hirschsprung’s disease, short-chain fatty acids, hirschsprung-associated enterocolitis

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Article available in :
Volume 3, Issue 2, 2026
Page : 43-46
https://doi.org/10.51271/SOC-0067
Article Information
Received : 09 Mar 2026
Accepted : 09 Nis 2026
Published : 27 Nis 2026
Corresponding Author :

Riana Pauline Tamba: Division of Pediatric Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

[email protected]
Citation : Tamba RP, Kristianto TA, Yusra Y. Comparison of short-chain fatty acid (SCFA) patterns in children with and without Hirschsprung’s disease. Surg Child. 2026;3(2):43-46. doi:10.51271/SOC-0067

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