SOC
Surgery on Children

Surgery on Children Journal aims to publish issues related to Pediatric Surgery, Pediatric Neurosurgery, Pediatric Plastic Surgery, Pediatric Cardiovascular Surgery, Pediatric Orthopedic Surgery, Pediatric Vascular Surgery, Pediatric Gynecology and Obstetrics, Pediatric Ear Nose Throat, Ophthalmology, Pediatric Anesthesiology and Reanimation, Pediatric Urology, Pediatric Surgical Intensive Care Clinic, and other clinical surgery fields on children of the highest scientific and clinical value at an international level and accepts articles on these topics.

eISSN: 3023-7289
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microRNAs (miRNAs) targeting oxidant-antioxidant mechanisms in primary ciliary dyskinesia and cystic fibrosis: epigenetic insights into therapeutic biomarkers
Abstract
A comprehensive understanding of miRNAs as epigenetic regulators of genes related to mitochondrial dynamics reflecting oxidant-antioxidant equilibrium, particularly hsa-miR-369-3p, hsa-miR-381-3p and hsa-miR-382-3p, may provide critical insights to improve therapeutic outcomes and offer substantial translational relevance in these rare diseases.

Keywords : Cystic fibrosis, miRNA, oxidative stress, primary ciliary dyskinesia

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1. Despotes KA, Zariwala MA, Davis SD, Ferkol TW. Primary ciliary dyskinesia: a clinical review.Cells. 2024;13(11):974. doi:10.3390/cells 13110974
2. Pereira R, Barbosa T, Cardoso AL, Sá R, Sousa M. Cystic fibrosis and primary ciliary dyskinesia: similarities and differences.Respir Med. 2023;209:107169. doi:10.1016/j.rmed.2023.107169
3. Finotti A, Gambari R. Perspectives in microRNA therapeutics for cystic fibrosis. Noncoding RNA. 2025;11(1):3. doi:10.3390/ncrna11010003
4. Kartal Y, Bozdemir Özel C, Çakmak A, et al. The relationship between lung function, exercise capacity, oxidant and antioxidant response in primary ciliary dyskinesia and cystic fibrosis.Turk J Pediatr. 2024;66(3): 309-322. doi:10.24953/turkjpediatr.2024.4581
5. Bhattacharyya S, Balakathiresan NS, Dalgard C, et al. Elevated miR-155 promotes inflammation in cystic fibrosis by driving hyperexpression of interleukin-8. J Biol Chem. 2011;286(13):11604-11615. doi:10.1074/jbc.M110.198390
Article available in :
Volume 3, Issue 2, 2026
Page : 69-70
https://doi.org/10.51271/SOC-0073
Article Information
Received : 17 Şub 2026
Accepted : 11 Mar 2026
Published : 27 Nis 2026
Corresponding Author :

Yasemin Kartal: Department of Physiology, Faculty of Medicine, Kırklareli University, Kırklareli, Turkiye

[email protected]
Citation : Kartal Y. “microRNAs (miRNAs) targeting oxidant-antioxidant mechanisms in primary ciliary dyskinesia and cystic fibrosis: epigenetic insights into therapeutic biomarkers”. Surg Child. 2026;3(2):69-70. doi:10.51271/SOC-0073

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