SOC
Surgery on Children

Surgery on Children Journal aims to publish issues related to Pediatric Surgery, Pediatric Neurosurgery, Pediatric Plastic Surgery, Pediatric Cardiovascular Surgery, Pediatric Orthopedic Surgery, Pediatric Vascular Surgery, Pediatric Gynecology and Obstetrics, Pediatric Ear Nose Throat, Ophthalmology, Pediatric Anesthesiology and Reanimation, Pediatric Urology, Pediatric Surgical Intensive Care Clinic, and other clinical surgery fields on children of the highest scientific and clinical value at an international level and accepts articles on these topics.

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Original Article
The effect of combined use of oxybutynin and fulguration in children with PUV: experience in a tertiary center in Bangladesh
Abstract
Aims: Posterior Urethral Valve (PUV) is a common congenital urethral obstruction leading to significant morbidity. Despite successful fulguration of posterior urethral valve, the bladder dysfunction persists in most of the cases. Oxybutynin, an anticholinergic drug is commonly used to manage this bladder dysfunction. This study aimed to assess the impact of oxybutynin on bladder and urinary tract function in children with valve fulguration.
Methods: A retrospective observational study was conducted on 41 children who underwent PUV fulguration at a tertiary care center in Bangladesh between 2020 and 2023. All subjects received oxybutynin for at least 6 months post-fulguration. Bladder wall morphology, hydronephrosis, vesicoureteral reflux (VUR), and post void residues (PVR) were assessed. Side effects of oxybutynin were also documented.
Results: All patients had bilateral hydroureteronephrosis (HUN), except one, who was with unilateral HUN during primary diagnosis. Complete resolution of bilateral HUN was seen in Renal USG 14 patients at 6 months post fulguration. Correction of VUR documented in 13 units out of 32 units. Mean serum creatinine decreased to 0.52 ± 0.22from 0.73 ± 0.52 within 6 months of fulguration. Four patients exhibited significant PVR, leading to clean intermittent catheterization (CIC) initiation.
Conclusion: Combined with PUV fulguration and oxybutynin therapy appears to be effective in improving bladder function. Further prospective studies incorporating urodynamic evaluations are warranted to validate these findings.

Keywords : Posterior urethral valve, oxybutynin, fulguration

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Article available in :
Volume 2, Issue 1, 2025
Page : 1-4
https://doi.org/10.51271/SOC-0025
Article Information
Received : 02 Eki 2024
Accepted : 25 Eki 2024
Published : 20 Oca 2025
Corresponding Author :

Ipsita Biswas: Department of Pediatric Urology, Bangladesh Shishu Hospital and Institute, Dhaka, Bangladesh

[email protected]
Citation : Biswas I, Sultana S, Huq U, Chacraborty AK. The effect of combined use of oxybutynin and fulguration in children with PUV: experience in a tertiary center in Bangladesh. Surg Child. 2025;2(1):1-4.

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