SOC
Surgery on Children

Surgery on Children Journal aims to publish issues related to Pediatric Surgery, Pediatric Neurosurgery, Pediatric Plastic Surgery, Pediatric Cardiovascular Surgery, Pediatric Orthopedic Surgery, Pediatric Vascular Surgery, Pediatric Gynecology and Obstetrics, Pediatric Ear Nose Throat, Ophthalmology, Pediatric Anesthesiology and Reanimation, Pediatric Urology, Pediatric Surgical Intensive Care Clinic, and other clinical surgery fields on children of the highest scientific and clinical value at an international level and accepts articles on these topics.

eISSN: 3023-7289
Creative Commons CC BY-NC-ND 4.0 International License.

Online Manuscript System

Index
Case Report
Caudal analgesia application with bupivacaine in a pediatric patient with glucose-6-phosphate dehydrogenase enzyme deficiency; case report
Abstract
Glucose-6-phosphate dehydrogenase enzyme has a cells protecting feature from oxidative damage. Glucose-6-phosphate Dehydrogenase Enzyme Deficiency is a hereditary disease that causes hemolysis in cases of deficiency due to mutation in the X chromosome, due to oxidative stresses such as some drugs, chemicals or infection. The preoperative Hb of a 4-year-old patient who was to undergo circumcision surgery was determined as 8.9 g/dL. Since increased bleeding was not expected during this procedure, no attempt was made to increase the hemoglobin value. After the induction of general anesthesia with sevoflurane 8%, 1 ml/kg of 0.25% bupivacaine was administered caudally to the patient. The hemodynamic findings remained within normal limits during the surgical procedure. In the follow-up, it was determined that the pain score was low and that no additional analgesic drugs were required. Afterwards, no additional hematological abnormalities were detected and the patient was discharged two days later. We believe that during surgery, when routine monitoring measures are taken and conditions that may cause stress to the patient such as hypotension, hypoxemia, and dehydration are avoided, the patient's anesthesia and postoperative pain can be controlled with a general anesthetic gas such as sevoflurane and a local anesthetic such as bupivacaine, with attention to toxic doses.

Keywords : Bupivacaine, caudal analgesia, glucose-6-phosphate dehydrogenase deficiency, postoperative analgesia, sevorane

Download Article


1. Luzzatto L, Ally M, Notaro R. Glucose-6-phosphate dehydrogenasedeficiency. Blood. 2020;136(11):1225-1240. doi:10.1182/BLOOD.2019000944
2. Elyassi AR, Rowshan HH. Perioperative management of the glucose-6-phosphate dehydrogenase deficient patient: a review of literature.Anesth Prog. 2009;56(3):86. doi:10.2344/0003-3006-56.3.86
3. Takahashi N, Ogawa T, Wajima Z, Omi A. Dexmedetomidine-basedintravenous anesthesia of a pediatric patient with glucose-6-phosphatedehydrogenase (G6PD) deficiency: a case report. Medicine (Baltimore).2017;96:21. doi:10.1097/MD.0000000000006986
4. Kamerbeek NM, Van Zwieten R, De Boer M, et al. Molecular basisof glutathione reductase deficiency in human blood cells. Blood.2007;109(8):3560-3566. doi:10.1182/BLOOD-2006-08-042531
5. Belfield KD, Tichy EM. Review and drug therapy implications ofglucose-6-phosphate dehydrogenase deficiency. Am J Health SystPharm. 2018;75(3):97-104. doi:10.2146/AJHP160961
6. Valiaveedan S, Mahajan C, Rath GP, Bindra A, Marda MK. Anaestheticmanagement in patients with glucose-6-phosphate dehydrogenasedeficiency undergoing neurosurgical procedures. Indian J Anaesth.2011;55(1):68-70. doi:10.4103/0019-5049.76597
7. Kaplan M, Wong RJ, Stevenson DK. Hemolysis and glucose-6-phosphatedehydrogenase deficiency-related neonatal hyperbilirubinemia.Neonatology. 2018;114(3):223-225. doi:10.1159/000489820
8. Youngster I, Arcavi L, Schechmaster R, et al. Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review.Drug Saf. 2010;33(9):713-726. doi:10.2165/11536520-000000000-00000
9. Goi T, Shionoya Y, Sunada K, Nakamura K. General anesthesia in aglucose-6-phosphate dehydrogenase deficiency child: a case report.doi:10.2344/anpr-66-01-05
10. Takahashi N, Ogawa T, Wajima Z, Omi A. Dexmedetomidine-basedintravenous anesthesia of a pediatric patient with glucose-6-phosphatedehydrogenase (G6PD) deficiency A Case Report. Medicine (Baltimore).2017;96(21):1-3. doi:10.1097/MD.0000000000006986
11. Shah RD, Suresh S. Applications of regional anaesthesia in paediatrics.Br J Anaesth. 2013;111 Suppl 1(Suppl 1). doi:10.1093/BJA/AET379
12. Gómez Gómez S, Ruano Santiago M, Rodríguez Morillo A, PérezMuñoz AM, Echevarría Moreno M. Anesthetic management of glucose6-phosphate dehydrogenase deficiency. Rev Esp Anestesiol Reanim.2023;70(4):235-239. https://pubmed.ncbi.nlm.nih.gov/36842683/
Article available in :
Volume 1, Issue 3, 2024
Page : 71-74
https://doi.org/10.51271/SOC-0017
Article Information
Received : 20 Tem 2024
Accepted : 15 Ağu 2024
Published : 30 Eyl 2024
Corresponding Author :

Cevdet Yardımcı: Department of Anesthesiology and Reanimation, Faculty of Medicine, Yozgat Bozok University, Yozgat, Turkiye

[email protected]
Citation : Kara M, Yardımcı C, Andıran Şenaylı Y. Caudal analgesia application with bupivacaine in a pediatric patient with glucose-6-phosphate dehydrogenase enzyme deficiency; case report. Surg Child. 2024;1(3):71-74.

Read: 38
Cited: 0
Download : 22
_Footer